Landmark, peer-reviewed analysis adds clinical relevance for your everyday practice

  1. Results reported by sites healthy and plaque-free—as opposed to whole-mouth plaque/gingivitis reduction data—allow you to easily set targets for your practice
  2. This analysis reviewed data on the additive benefits of LISTERINE® from randomized, observer-blinded, placebo-controlled studies, including both published and unpublished data
  3. Evidence was drawn from a larger-than-usual population of N>5000 subjects; single studies have an average of 163 subjects

The most robust collection of clinical data of its kind


29 Studies of 6 Months’ Duration Over 5000 Patients 3 Countries: United States, Canada & Brazil  4 Decades of Data 500,000+ Sites
  • 1 landmark analysis: enabled broader, more clinically relevant conclusions

Analysis compared the results of 2 treatment groups

Control group

  • Mechanical methods (MM) alone
  • 2562 patients

Experimental group

  • 2544 patients

Sitewise analysis evaluated efficacy at multiple sites per tooth across the entire mouth

Plaque index (PI): 6 sites per tooth

  • Plaque-free sites were defined as those with small pieces of plaque (1) or no plaque (0), based on the PI score

Modified gingival index (MGI): 4 sites per tooth

  • Healthy sites were defined as those with mild (1) to no (0) inflammation, based on the MGI scores

LISTERINE® users were more likely to have a cleaner, healthier mouth vs. MM alone


LISTERINE® users had nearly 5x more plaque-free sites at 6 months vs. MM alone and over 2x more healthy gingival sites at 6 months vs. MM alone

LISTERINE® users had more plaque-free sites and more healthy sites — even in the hardest-to-reach areas of the mouth


Percentage of patients “plaque-free” by site: LISTERINE® vs. MM alone


Percentage of patients “healthy” by gingival site: LISTERINE® vs. MM alone

Reference: 1. Araujo MWB, Charles CA, Weinstein RB, et al. Meta-analysis of the effect of an essential oil–containing mouthrinse on gingivitis and plaque. J Am Dent Assoc. 2015;146(8):610-622 and/or post hoc analyses of data.