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How Listerine® Works:4 Essential Oils.

1 Bold Mouthwash.

Curious how LISTERINE® Mouthwash has such a bold effect on oral health? The answer is simple: eucalyptol, menthol, methyl salicylate, and thymol—the 4 essential oils in LISTERINE®.

 THE ANTIBACTERIAL ACTION OF LISTERINE® COMES FROM ITS UNIQUE FORMULA, WHICH CONTAINS A FIXED COMBINATION OF 4 ESSENTIAL OILS FOUND IN NATURAL PLANT SOURCES. 

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 WHAT DOES LISTERINE DO? 

  • LISTERINE® Mouthwash reaches every site in the mouth, reducing plaque biofilm in areas that patients may miss when brushing and interdental cleaning

  • The 4 essential oils in LISTERINE® penetrate deeply into the bottom layers of the plaque biofilm, breaking down its structure in places that are more difficult for a toothbrush or interdental cleaning device to access1-3

 A BOLD ACHIEVEMENT: BETTER PLAQUE REDUCTION THAN CPC.4 

  • LISTERINE® penetrates deeper into the plaque biofilm than cetylpyridinium chloride (CPC) mouthwash

  • Confocal microscopy reveals a higher ratio of dead bacteria to living bacteria within the biofilm with LISTERINE® than with CPC mouthwash or negative control

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 THE 4 ESSENTIAL OILS IN LISTERINE® KILL 1.8X MORE BACTERIA THAN CPC MOUTHWASH.4 

*Based on self-reported data from a survey of patients in Brazil, Japan, Thailand, United Kingdom, and United States (N=4134).

 References:  1. Foster JS, Pan PC, Kolenbrander PE. Effects of antimicrobial agents on oral biofilms in a saliva-conditioned flowcell. Biofilms. 2004;1(1):3-10. 2. Minah GE, DePaola LG, Overholser CD, et al. Effects of 6 months use of an antiseptic mouthrinse on supragingival dental plaque microflora. J Clin Periodontol. 1989;16(6):347-352. 3. Walker C, Clark W, Wheeler T, Lamm R. Evaluation of microbial shifts in supragingival plaque following long-term use of an oral antiseptic mouthrinse. J Dent Res. 1989;68:412. 4. Data on file, Johnson & Johnson Consumer Inc.

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Site last updated: July 06, 2026

Disclaimer: Advice on oral care provided on this site is not intended as a substitute for professional medical/dental advice, diagnosis, or treatment.

Always seek the advice of your physician, dental professional, or other qualified health provider with any questions you may have regarding a medical/dental condition.