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Bold support for

a bold mouthwash

LISTERINE® is an extensively researched mouthwash brand, with over 4 decades of clinical support. Bold evidence like this proves that better oral health is not only possible, but achievable.

 The Effect of LISTERINE® on Reduction of Existing Plaque and Gingivitis1 

- Lamster IB, Alfano MC, Seiger MC, Gordon JM. The effect of LISTERINE® on reduction of existing plaque and gingivitis. Clin Prev Dent. 1983;5:12-16.

The Effect of LISTERINE® Removing Plaque from Teeth

 Objective 

Evaluate the effect of LISTERINE® on existing dental plaque and gingivitis over the course of a 6-month trial (N=129).

 Methodology 

Randomized, double-blind study of subjects (aged ≥18 years) with preexisting plaque and gingivitis.

 Results 

When compared with water, LISTERINE® reduced dental plaque by 22.2% and gingivitis by 28.2% at 6 months. When compared with vehicle, LISTERINE® reduced dental plaque by 20.8% and gingivitis by 27.7% at 6 months, respectively.

 Conclusion 

LISTERINE® when used twice daily for 30 seconds, is effective in controlling plaque accumulation and gingivitis in a population that did not receive a prophylaxis.

*LISTERINE® is not indicated for use in the treatment of xerostomia.
Subjects were instructed to follow their usual oral hygiene regimen and use of dental floss was permitted to remove trapped food.
26.9% hydroalcoholic vehicle containing all ingredients in LISTERINE® except its essential oils.

 Reference:   1.  Lamster IB, Alfano MC, Seiger MC, Gordon JM. The effect of LISTERINE® on reduction of existing plaque and gingivitis. Clin Prev Dent. 1983;5:12-16.

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BIG RESULTS FROM THE BIGGEST LISTERINE® ANALYSIS.

EVER.

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Site last updated: July 06, 2026

Disclaimer: Advice on oral care provided on this site is not intended as a substitute for professional medical/dental advice, diagnosis, or treatment.

Always seek the advice of your physician, dental professional, or other qualified health provider with any questions you may have regarding a medical/dental condition.